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KMID : 0613820110210060783
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Journal of Life Science
2011 Volume.21 No. 6 p.783 ~ p.787
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Thaumatin Isolated from Katemfe Fruit of Thaumatococcus daiellii Inhibits 3T3-L1 Adipocytes Differenciation
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Cha Jae-Young
Jeong Jae-Jun
Yang Hyun-Ju
Park Jun-Seok
Kim Hyun-Woo
Kim Su-hyun
Jung Hae-Jung
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Abstract
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The effects of thaumatin isolated from katemfe fruit of Thaumatococcus daiellii Benth on 3T3-L1 preadipocyte differentiation was investigated in vitro. 3T3-L1 adipocytes were treated with various concentrations of thaumatin ranging in 0-5 μM. Thaumatin reduced fat accumulation in differentiated 3T3-L1 adipocytes in a dose-dependent manner. 3T3-L1 cell proliferation was 97.0 and 88.3% at 1 and 3 μM after 8 days of thaumatin treatment, respectively. Thaumatin showed a potent inhibitory effect on stained lipid droplets at a concentration of 3 μM. Thaumatin reduced triglyceride accumulation in differentiated 3T3-L1 cells in a dose-dependent manner, compared with positive control cells. This study provides basic information on the anti-obesity activity of thaumatin.
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KEYWORD
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3T3-L1 adipocyte cells, thaumatin, Thaumatococcus daiellii Benth, sweet-protein
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